Natural Product Solutions
Results are encouraging
Natural products and their derivatives have long been a rich source of therapeutics, particularly in areas such as infectious disease and cancer. Approximately 25 percent of prescription drugs are plant-derived; in cancer, the percentage of approved natural product-based compounds is close to 50 percent. However, the chemical diversity in natural products has remained largely unexplored, in part due to challenges in both identifying promising bioactive specialized metabolites, which may only be produced under certain conditions such as environmental stress, and in producing enough quantities for both study and treatment.
The emerging engineering platform identifies and synthesizes novel bioactive compounds by exploiting the molecular design machinery of plant and microbial species. The approach involves:
- inducing specialized metabolite synthesis in cell culture through the application of stress-mimicking compounds,
- drug screening in disease-specific assays,
- production in quantity for preclinical development through the design and optimization of artificial biosynthetic pathways and host systems, and
- engineering new molecules with tailored properties based on the discovery of novel enzymes and their integration into biosynthetic pathways
The Precision Botanical API is catalyzed by a unique ~2000 species plant tissue culture collection representing almost 10 percent of plant genera and 50 percent of plant families. The collection remains largely unexplored for therapeutic compounds.